Transcriptome Stability in Metabolic Diseases

Application deadline closed.

Job Description

The research of the lab focuses on the role of transcriptome stability in metabolic homeostasis. We have built a comprehensive research platform centering on metabolic physiology study, complemented by bioinformatic analysis and RNA molecular biology. The individual will be expected to establish the exact molecular mechanisms governing metabolism, thereby facilitating the development of new therapies for obesity-related diseases.

As the population of obesity is increasing in many countries, much interest have been attracted to understand the mechanism underlying obesity and its related metabolic diseases. The current understanding of these questions is mainly at the transcriptional regulation and protein signal pathway levels. However, we do not understand how post transcriptional RNA metabolism contributes to the metabolic homeostasis at physiological conditions and how these regulations are dysregulated in pathological conditions. Our research specifically focuses on the role of transcriptome stability in metabolic homeostasis. Using adipocytes as a model system, we have developed a comprehensive platform covering computational analysis, molecular biology, and animal physiology characterization. We have identified a few key regulators such as Ybx2 and HuR proteins in the RNA stability regulation in adipose tissue and have generated genetic mouse models to study their physiological function and molecular mechanism.

Responsibilities

Independently carry out the design and execution of experimental research required by the research component of the project.
Write and review research papers, present research outcomes, conceptualize new ideas, and develop plans for independent research which could have a considerable influence and impact on the relevant field attracting research funding.
Develop connections with local and international researchers for collaboration work

Focus of Job Responsibilities

70% – Ongoing Research
-Design and implementation of hypothesis-driven research projects

15% – Analysis & Review
-Analysis and review of generated data and reviewing previously reported scientific literature

15% – Scientific writing
-Including reporting research findings in manuscripts for publication in peer-reviewed journals and grant writing
-Generation of figures for manuscripts and grants proposals

Work Location

The Research & Innovation Office (RIO) and The Hormel Institute endorses a “work with flexibility” approach that offers a welcoming and flexible work environment where everyone is inspired to do their best. Work location options include working fully remote, partially remote, or entirely in the office and are based on the work of the position. Some on-site work may be necessary for certain positions, even those designated as fully remote. Because we are a land-grant institution that serves the state, the University will continue to- in most cases- expect employees to live in Minnesota.

This position has been designated as Flexible Work Profile One. Flexible Work Profile One is expected to work primarily on-site. Your office will be located at The Hormel Institute in Austin, MN. The Hormel Institute management retains the right to modify flexible work arrangement agreements on a temporary or permanent basis for any reason at any time.

Required Qualifications
-Ph.D., DDS, DVM, JD, MD or equivalent

Preferred Research Skills

-Experience in molecular biology, biochemistry and cell biology is required
-A proven track record in the form of decent publications
-Experience with metabolism research is highly desirable

How should applicants apply?
External URL
External application URL