Postdoctoral positions in stem cell and metabolism

Application ends: May 1, 2024
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Job Description

To begin in or shortly after May 2024. The successful candidates are expected to spearhead innovative research projects related to one of the following areas:

1. Satellite cell biology and muscle regeneration. We use mouse models and human cells to study signaling mechanisms and metabolic pathways that regulate regenerative function of muscle stem cells called satellite cells (PMID: 17540178; 22493066; 28094257; 33068545). Recent single cell RNA-seq studies in the lab has led to the discovery of a subset of satellite cells with immune cell properties (PMID: 32248062). Ongoing studies aim to dissect the origin and function of these immunomyoblasts (i.e. immune gene-expressing myoblasts). Additional interests of the lab are to understand the role of lipid droplets and fatty acid metabolism in satellite cell biology (PMID: 35045287; 37063787; 37334900; 37883229).

2. Plasticity and regulation of white, beige and brown adipocytes. Following our discovery of the common origin of brown fat and skeletal muscle (PMID: 18719582), we have been exploring the lineage origin, cell fate regulation and function of various fat cells (PMID: 22037676; 23047894; 23740968; 23781029). Ongoing studies combine our discovery with biomaterial approach to promote browning of white adipocytes to combat obesity and type 2 diabetes (PMID: 28624262; 31668904). Additional research aims to identify novel molecular regulators of adipocyte biology (PMID: 25038826; 33304767; 34669999; 35362877; 37816711).

3. Cancer stem cells and metabolism, of sarcomas especially liposarcoma. We are the first group to report a key role of Notch signaling activation in tumorigenesis of adipocytes, resulting in dedifferentiated liposarcoma (PMID: 27573812), the result is confirmed by others in mice and humans (PMID: 29515034; 36464833). Current efforts in the lab focus on how Notch signaling regulates cancer stem cell status and metabolism in liposarcoma and other sarcomas (PMID: 25805408; 32866607; 37433985).

The applicants should have a PhD or equivalent degree in life sciences or related fields, for example cell and developmental biology, biochemistry, physiology, or biomedical engineering. Experiences in cell culture, animal models, advanced microscopy, molecular biology techniques, data mining and analysis (of RNA-seq, proteomics, metabolomics and lipidomics data) will be preferred. Strong writing skills and prior publications in relevant field are required. Successful candidates will be provided with excellent compensation and career development opportunities (20+ trainees from the Kuang lab have taken faculty/scientist positions in USA, Japan, and China ), as well as freedom to explore the endless frontiers of science in an inclusive and supportive working environment.

Inquiries and applications (including CV, name/email address of 3 referees, and a brief description of research interests) should be addressed to: skuang@purdue.edu.

How should applicants apply?
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