Yuri Bunimovich
Job Description
Yuri Bunimovich is a physician-scientist at the University of Pittsburgh who serves patients as a surgical dermatologist and studies the mechanisms of tumorigenesis and immune escape of melanoma and non-melanoma skin cancer in his laboratory. Yuri completed his PhD is Chemistry and Chemical Engineering at CalTech before continuing onto a postdoctoral position in molecular and medical pharmacology at the California NanoSystems Institute in Los Angeles, California. This research background, combined with his active role in patient care, puts Yuri in a strong position to translate findings from the laboratory to the clinic. A central goal of the Bunimovich lab is to aid the development of new medical technologies and therapeutics for cutaneous malignancies. By joining the lab as a postdoctoral fellow, you will work in collaboration with immunologists, chemists, and clinicians to solve compelling questions about the cause and treatment of skin cancers.
Research Projects in the Lab include:
1.) Neuroimmune regulation of melanoma and non-melanoma skin cancer progression. These studies focus on understanding how sensory neurons and Schwann cells contribute to cancer progression and metastasis, specifically via immunomodulatory mechanisms.
2.) Pathogenesis of lipid redox dysregulation in the inflammatory skin diseases. These studies explore novel signaling mechanisms of dysregulated redox lipid products generated in keratinocytes and immune cells, and their relevance to psoriasis and atopic dermatitis.
3.) Role of ferroptosis in neoplastic and inflammatory skin diseases. These studies focus on ferroptosis in different cellular compartments in cutaneous diseases and on targeting ferroptosis as a novel therapeutic approach to treat neoplastic and inflammatory skin diseases.
4.) Glial functions in cancer, skin inflammation, wound healing and peripheral neuropathy. These studies focus on peripheral glial cells, and their role in a wide range of physiological and pathological processes in the skin.
