Job Description

The Brody lab is broadly focused on the molecular signals that underlie cardiac disease onset and progression. We have a strong interest in understanding how intracellular signaling is compartmentalized and regionally controlled by lipid modifications that modulate the function of signaling molecules in various cell types of the heart to control cardiac physiology and pathogenesis. We utilize a combination of mouse genetics, biochemistry, and molecular and chemical biology techniques to gain insight into pathophysiological signaling mechanisms that contribute to human cardiovascular disease.

One area we are actively investigating is how the zDHHC family of S-acyl transferase enzymes control signaling in cardiac cells. We found palmitoylation of signaling proteins catalyzed by some of these enzymes at the surface of the cardiomyocyte Golgi membrane functions  as a critical mechanism governing cardiac stress adaptation and remodeling, including instrumental roles in regulation of exocytosis and natriuretic peptide release, cytokine receptor signaling, and myocardial oxidative stress. We have a broader interest in identifying and elucidating pharmacological strategies to inhibit intracellular signaling pathways that promote cardiac hypertrophy and failure.

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