JT Elder

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Job Description

The Elder laboratory utilizes tools of molecular biology and genetics to better understand several human skin diseases. Dr. Elder’s lab is a world leader in the use of genetic linkage and association techniques to learn more about how the immune system activates the epidermal wound healing mechanism in psoriasis, and triggers joint destruction in psoriatic arthritis. In 2006, his laboratory identified HLA-Cw6 as the disease allele at PSORS1, the major psoriasis susceptibility locus in the major histocompatibility complex (MHC). His current efforts in this area are focused on identification of psoriasis susceptibility genes outside the MHC, with nine loci confirmed thus far. His laboratory also has a long-standing interest in the role of the EGF receptor (also known as ErbB1) as an activation signal for epidermal wound healing and carcinogenesis. Active projects in this area are exploring the roles of autocrine EGF-like growth factors in psoriasis, wound healing and cancer. Finally, Dr. Elder’s laboratory has also identified somatic mutations in melanocytic nevi and melanomas of varying degrees of progression.

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