The Keller Lab currently focuses on several disciplines that fall under studies of cancer metastasis. Specifically, the biology of bone metastasis, including the role of the microenvironment; and mechanisms of chemoresistance. We explore for genes that regulate metastasis and the interaction between the host microenvironment and cancer cells. We are performing single cell multiomics and spatial analysis to enable us to identify rare cell populations and promote precision medicine. Our research methodology uses a combination of molecular, cellular, and animal studies. The majority of our work is highly translational to provide clinical relevance to our work.